Effect of Ribavirin Given in Small-Particle Aerosols on Selected Clinical and Hematological Responses.
Abstract
The effect of 40 mg/kg/day of ribavirin given for 4 days by aerosol to squirrel monkeys was compared to 40 and 400 mg/kg orally and to additional monkeys given water by the aerosol or oral route. Suppression of erythrocyte and hemoglobin levels occurred with the high oral dose, and all groups of ribavirin-treated monkeys had some dyspnea and lethargy. In view of these transient effects short courses of ribavirin may be administered safely. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 08, 1979
- Accession Number
- ADA067169
Entities
People
- Edward L. Stephen
- R. F. Berendt
Organizations
- United States Army Medical Research Institute of Infectious Diseases