Mammalian Toxicity of Munitions Compounds. Phase I. Acute Oral Toxicity, Primary Skin and Eye Irritation, Dermal Sensitization, Disposition and Metabolism and Ames Tests of Additional Compounds
Abstract
Tests indicated that 3,5-Dinitrotoluene (3,5-DNT) was the most potent of all DNT isomers in oral acute doses to rats and mice. 2-Amino-4, 6-DNT (2- ADNT) and its isomer, 4-ADNT, were the least potent in rats and female mice, and comparable to 2,3-DNT and 2,4-DNT in male mice. 3.5-DNT and 4-ADNT were not irritating to rabbit skin; 2-ADNT was a mild irritant. All three compounds were not irritating to rabbit eyes and not sensitizing to guinea pigs. 3,5-DNT and 4- ADNT were absorbed from the gastrointestinal tract, metabolized and excreted in the urine. In the Ames test, 1,3-dinitroglycerin (1,3-DNG), 1-mononitroglycerin (1-MNG), nitrocellulose and white phosphorus were not mutagenic. Trinitrotoluene (TNT) 2,4-DNT, 2,5-DNT, tetranitromethane (TNM) and 1,2-DNG were mutagenic at 10 to 30 microgram/plate in one or more strains. TNM was bactericidal without activation. 1,2-DNG was nonmutagenic with activation. 2,3-DNT, 2,6-DNT, 3,5-DNT, trinitroglycerin and 2-MNG were weakly mutagenic, with mutagenic results at 100 or 1,000 microgram/plate in one or more strains.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 08, 1978
- Accession Number
- ADA069333
Entities
People
- Danny O. Helton
- Harry V. Ellis Iii.
- John R. Hodgson
- Laurel M. Halpap
- Shang W. Hwang
Organizations
- MRIGlobal