Mechanism of Innate Resistance of Flaviviral Encephalitis.
Abstract
Previous investigations of genetic resistance of lethal flaviviral encephalitis in mice suggested that resistance is expressed phenotypically through-nonimmunological virus-host interactions. Thus tissues from resistant mice are believed to be inherently less capable, or less willing, to support viral replication than tissues from resistant mice. In contrast, previous work from our laboratory indicates that phenotypic expression of genetic resistance to a flavivirus also involves immunological mechanisms. Taken collectively, the data indicate that genetic resistance is a multifactorial process. The studies utilized our model system: the response of 2 congenic strains of histocompatible C3H miceo to infection with Banzi virus. One strain (C2H/He) is highly susceptible to lethal infection with Banzi virus and the other strain (c3H/RV) is highly resistant to lethal infection with this virus. Experiments planned for the year were to examine the ultra-structural morphogenesis of viral encephalitis, evaluate a potential role for defective interfering particles in resistance to infection and extend characterization of immunological responses to Banzi virus. Comparisons of response between resistant and susceptible mice, in virto or in vivo were to be stressed for each of the studies.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 01, 1978
- Accession Number
- ADA069710
Entities
People
- Pravin N. Bhatt
- Robert O. Jacoby
Organizations
- Yale University