Composition of Cerebral Fluids in Goats Adapted to High Altitude,
Abstract
The ionic composition of cerebral ISF was explored in 6 unanesthetized goats at sea level (SL) and again after 5 days at simulated high altitude (HA) of 4300 m, by measuring net transependymal fluxes of HCO3 ion, Cl ion and lactate during ventriculo-cisternal perfusions with lactate-free artificial CSF with various (HCO3 ion) and (Cl ion): concentration of an ion in cerebral ISF is indicated by concentration of that ion in the inflowing perfusate, that produces zero flux. We conclude that, at SL, (HCO3 ion) and (Cl ion) in CSF were the same as in cerebral ISF, which is in agreement with previously published findings. In goats adapted to HA, (Cl ion) in cerebral ISF remained equal to (Cl ion) in CSF, while (HCO3 ion) in cerebral ISF was demonstrably lower, and (lactate) presumably higher, than in CSF. The fluid surrounding the central chemoreceptors appears to be more acidic in goats acclimatized to HA than at SL, in spite of the alkalosis in cisternal CSF. This may contribute to ventilatory acclimatization to HA.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 23, 1979
- Accession Number
- ADA070142
Entities
People
- Douglas E. Wolfe
- R. A. Gabel
- V. Fencl
Organizations
- United States Army Research Institute of Environmental Medicine