Human Platelet Senescence.
Abstract
Evidence that large-heavy platelets (megathrombocytes) are released early from the bone marrow and become smaller-lighter platelets with time under basal conditions. Heterogeneity of platelet protein content as determined by SDS-polyacrylamide gel electrophoresis of cell sap proteins of various platelet populations isolated by differential centrifugation in plasma. Heterogeneity of platelet monoamine oxidase activity: correlation with platelet protein density. Evidence that megathrombocyte number determines platelet function and that significant numbers of megathrombocytes are routinely discarded by conventional methods of preparation of platelet-rich plasma. Evidence that intact microtubules are required for platelet aggregation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 18, 1978
- Accession Number
- ADA070589
Entities
People
- Simon Karpatkin
Organizations
- NYU Langone Health