Classes and Properties of Human Antibodies.

Abstract

Multiple injections of ovomucoid were given to mice with ongoing prolonged IgE antibody production to that antigen. Two inbred strains and antigen doses ranging from 0.05 to 5 micrograms each injection, given intradermally and subcutaneously, were used. Mice treated in this manner showed a marked diminution of the IgE antibody booster response as compared to controls. This decrease in booster response was antigen-specific. In addition, a protective effect from anaphylaxis was indicated. The mouse model continues to be a valuable tool for studies of certain IgE-mediated diseases. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1975
Accession Number
ADA072071

Entities

People

  • Bernard B. Levine

Organizations

  • New York University

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Allergic Diseases
  • Anaphylaxis
  • Animals
  • Antibodies
  • Biomedical Research
  • Diseases And Disorders
  • Hydroxides
  • Hypersensitivity
  • Laboratory Animals
  • Maryland
  • New York
  • Plastic Explosives
  • Production
  • Schools
  • Universities

Fields of Study

  • Biology
  • Medicine

Readers

  • Allergy and Immunology.
  • Immunology
  • Mathematics or Statistics