Studies in Septic Shock and other Pathophysiologic Effects of Infection in Injured Patients.
Abstract
This report includes investigations on the following: (1) Definition and classification of microbial and non-microbial determinants of post-trauma infections. (2) Causes of changing patterns of surgical infections. (3) Mechanisms of pathogenicity of Pseudomonas aeruginosa. (4) Evaluation of Pseufomonas vaccine and hyperimmune glovulin in the prevention and control of Pseudomonas infections. (5) Factors responsible for cyclic variations in Staphylococcal antibiotic resistance. (6) Development and clinical application of indirect fluorescent antibody technics for rapid identification of Bacteroidaceae. (7) The measurement of pathophysiologic effects of clinical septic shock and comparison with those obtained in experimental animals by injections of E. coli endotoxin, the Staphylococcus aureus alpha exotoxin, or the alpha exotoxin of Cl. perfringens. The results emphasize that septic shock is a complex syndrome in which failures of the systemic and visceral arterial tissue perfusions are integral parts.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 31, 1975
- Accession Number
- ADA072549
Entities
People
- William A. Altemeier
Organizations
- University of Cincinnati