Effect of Anti-Parasite Chemotherapeutic Agents on Immune Reactions.
Abstract
Five agents, namely chloroquine phosphate (WR 1544), primaquine phosphate (WR 2975), quinine sulphate (WR 2976-5), quinine dihydrochloride monohydrate (WR 2976-HCl), and 1-1,3-dichloro-6-trifluoromethyl-9-phenanthryl-3-di-(n-butyl)amminopropanol hydrochloride (DTPA) (WR 171669), were studied for their effect on humoral response to sheep erythrocytes (SRBC) as measured by the plaque-forming cell (PFC) contents of spleens, delayed hypersensitivity (DH) reaction to SRBC, and phagocytic activity were studies in mice. Humoral PFC responses were not affected by WR 1544 or WR 2975. Quinine sulphate (WR 2976-S) and quinine dihydrochloride monohydrate (WR 2976-HCl) suppressed PFC responses when injected one day before, but enhanced these responses when injected one day after the antigen. the DH reactions were not affected significantly by any of the drugs except WR 1544 at the higher dose (100 mg/kg) injected one day post antigen. Phagocytic activity was depressed by the high dose (100 mg/kg) of WR 1544, WR 2975, both low and high doses (40 and 160 mg/kg0 of WR 2976-S and by the high dose of compounds WR 171669.
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 29, 1979
- Accession Number
- ADA073750
Entities
People
- Abdul Ghaffar
Organizations
- University of South Carolina