Scanning Electron Microscopy of Teeth in Autosomal Dominant Osteogenesis Imperfecta: Support for Genetic Heterogeneity.
Abstract
SEM studies were performed on 25 deciduous and permanent teeth from members of seven kindreds with autosomal dominant osteogenesis imperfecta (O.I.). Two families had normal teeth on clinical and radiological examination; five families had blue or brown opalescent teeth with specific radiologic findings. Enamel surfaces and prism organization were normal on all teeth. On fractured surfaces, the dentin tubules of normal teeth from patients with O.I. were evenly distributed and coursed regularly to the dentin-enamel junction. Opalescent teeth had few tubules; those tubules present were narrow, short, and tortuous. Dentin calcification fronts of normal teeth were composed of many mushroom shaped nodules, with regularly spaced openings on their surfaces. Calcification fronts of opalescent teeth were composed of irregularly spaced, small nodules, which varied greatly in size one from another; the nodules lacked tubule openings on their surfaces. The results of this study support the concept that two autosomal dominant O.I. syndromes exist, one in which all individuals with O.I. have normal teeth, and the other in which all with O.I. have blue or brown opalescent teeth. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 10, 1979
- Accession Number
- ADA074147
Entities
People
- John M. Brady
- L. Stefan Levin
- Michael Melnick
Organizations
- United States Army Institute of Surgical Research