Mechanism of Heat and Irradiation Synergism.
Abstract
This research program was undertaken to investigate the mechanism(s) by which bacterial spores can be sensitized to heat by gamma radiation treatments. The study empolyed spores of the public health significant anaerobic microorganism Clostridium perfringens. Based on biological, chemical and structural evidence, a model was developed to outline the mechanisms of synergism. It is proposed that radiation creates chemical lesions on the spore cortex which result in the loss of ability of this structure to maintain a dehydrated core. Hydration of the core would then result in an increased sensitivity of vital macromolecules found there. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 11, 1979
- Accession Number
- ADA074599
Entities
People
- Anthony J. Sinskey
- Reinaldo F. Gomez
Organizations
- Massachusetts Institute of Technology