The Physical and Functional Analysis of Interferons.
Abstract
Interferons are glycoproteins which induce states of cellular resistance to viral multiplication. It is now evident that interferons are capable of other biological actions such as the inhibition of cell division, macrophage activation, and suppression of intracellular multiplication of organisms other than virus. In order to determine if the various biological activities of each human interferon are mediated through common or distinct mechanisms, an interferon neutralization assay was developed which uses diminishing concentrations of specific anti-interferon serum to access the degree of neutralization of each biological activity. The results of similar studies using specific antibody to neutralize human fibroblast interferon antiviral activities on human and bovine cells revealed that not only was fibroblast interferon less active on bovine cells, but the slope of the neutralization curve on bovine cells differed from that on human cultures. This finding suggests that the mode of action of human fibroblast interferon on bovine cells differs from that on human cells.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 24, 1979
- Accession Number
- ADA074600
Entities
People
- Edward A. Havell