Comparative Metabolism of Propellant Hydrazines.
Abstract
Co-administration of hydrazine and carbon-14-methyl-methionine to rats and mice results in the methylation of liver DNA at the 7-position of guanine; this methylation occurs rapidly and is readily detectable one hour after hydrazine administration. No 7-methylguanine is found in animals given carbon-14-methyl-methionine alone. Administration of monomethylhydrazine (MMH) also results in the formation of 7-methylguanine in rat and mouse liver DNA but not in DNA from other tissues; MMH serves indirectly as the methyl donor. Administration of 1,1-dimethylhydrazine (UDMH) does not result in DNA methylation. The pattern of DNA methylation by hydrazine and MMH was not similar to that produced by 1,2-dimethylhydrazine (SDMH), a strong carcinogen. MMH and UDMH are metabolically oxidized to carbon dioxide at different rates by various tissues from rats, mice, and hamsters. Studies are in progress to further characterize DNA methylation in animals treated with propellant hydrazines, to determine whether the nitrogen atoms in these hydrazines form adducts with tissue DNA, and to identify all adducts formed by mass spectrometry. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Aug 01, 1979
- Accession Number
- ADA074634
Entities
People
- Ronald C. Shank
Organizations
- University of California, Irvine