Behavioral Effects of Acute Aerosol Exposure to N, N-Diethy-Meta-toluamide (M-Det), January - February 1979
Abstract
Groups of 10 male and 10 female rats were exposed for single 4-hour periods to aerosols of M-Det (an insect repellent) at concentrations estimated to be: (1) high enough to produce minimal toxic signs (4100 mg/cu m); (2) too low to produce toxic signs (2900 mg/cw m); or (3) somewhat lower (2300 mg/cu m). Concommitant controls were exposed to chamber air only. The rats were given a battery of behavioral tests as soon as the exposure period ended. The results of the battery permitted distinctions to be made between performance at all three levels and controls for both males and females. Tests included measures of activity, endurance, balance, tactical sensitivity, post exposure learning, and memory of a task learned the day before exposure. Necropsy did not show any gross physical changes as a result of the exposures. Thus, behavioral tests were able to establish changes resulting from acute exposures to M-Det at concentrations below those at which toxic signs could be detected.
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 01, 1979
- Accession Number
- ADA076939
Entities
People
- Richard A. Sherman
Organizations
- United States Army Medical Command