Behavioral Effects of Subchronic Aerosol Exposure to N,N-Diethyl-Meta-Toluamide (M-Det), February - May 1979. Phase 3,
Abstract
Groups of 10 male and 10 female rats were exposed to aerosols of M-Det (an insect repellent) for 6 hours per day, 5 days per week, for 13 weeks at concentrations of 1,5000 mg/cu m (1/4 LC50), 750 mg/cu m (1/8 LC50), 250 mg/cu m (1/24 LC50), or chamber air. The rats were given balance, tactile sensitivity and endurance tests during weeks 2, 4, 6, 8, 11, and 13 of the study. During the 13th week, they were also given memory, learning and activity tests. The results of the battery permitted distinctions to be made among performances at all three levels and controls for both males and females. Results of most tests repeated throughout the study changed in various ways as the study progressed. No toxic signs were observed in the participants when behavioral tests were carried out, and none died during the study. No gross abnormalities were evident upon necropsy at the end of the study, and groups of the same sex remained statistically similar in weight. Results of hematologic, histopathologic, chemical, and physiological tests will be reported separately. No changes in use of M-Det are recommended until further tests are run by other laboratories testing lower concentrations.
Document Details
- Document Type
- Technical Report
- Publication Date
- Nov 21, 1979
- Accession Number
- ADA077163
Entities
People
- Richard A. Sherman
Organizations
- United States Army Medical Command