Korean Hemorrhagic Fever.
Abstract
This report presents the results on (1) isolation of Korean hemorrhagic fever (KHF) virus from patients (2) antibody responses in animals (3) the ratio of clinical and subclinical infection (4) cultivation of the virus in a tissue culture cells and (5) vertical transmission of KHF virus in Apodemus agrarius. Out of 943 tested US military personnel stationed in Korea during years 1977 and 1978, five were sero-positive to KHF virus. It was confirmed that KHF virus grows well in human lung cancer cells (A549 cells) by the IFA method. Antibodies of sera from patients with KHF, with epidemic hemorrhagic fever in Japan, and with nephropathia epidemica, as well as with sera from infected animals were titrated simultaneously against KHF virus antigen, which was prepared in both apodemus lung tissues and in A549 cells. This showed that infected Apodemus lung tissues were more sensitive antigen system than infected A549 cells. Results of a limited study indicates that there is no vertical transmission of KHF virus in Apodemus agrarius.
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 31, 1979
- Accession Number
- ADA077341
Entities
People
- Ho Wang Lee
Organizations
- Korea University