The Biological Immune Response - A Review of Effect of Dietary Amino Acids.
Abstract
Despite the complexity and interacting components of the immune system, a definite pattern is emerging as the effects of dietary amino acids and proteins on the immune response, which include: (a) T-lymphocyte function can be altered by dietary proteins and amino acids; (b) only minor alterations of B-cell function have been observed in the protein-calorie malnutrition in humans; (d) concentration and hemolytic activity of serum complement, as well as opsonic activity decrease during PCM; and (e) the metabolic response to infectious desease can increase the protein deficiency of the host and indirectly affect the immune response. These effects on the iummune system are only observed during very severe PCM and would not account for the high incidence of infection that has been observed in the marginally malnourished child, which may be more related to the epidemic environment in which he lived. The consequence of altered immune response is not clearly defined and is largely circumstantial. During protein deprivation in experimental animals, most investigators have observed a decreased resistance to bacterial infections.s An increase in susceptibility to infectious disease with accompanied elevated rates of morbidity and mortality have been observed in children and adults with PCM.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 19, 1979
- Accession Number
- ADA079283
Entities
People
- Robert W. Wannemacher Jr.
Organizations
- United States Army Medical Research Institute of Infectious Diseases