Host Immune Response to Drug-Attenuated African Trypanosomes.

Abstract

We have examined the effects of berenil (diaminazene) on the ultrastructure and nucleic acid synthesis of mouse borne monomorphic T. brucei (EATRO 691A) in vivo. Trypanosomes isolated 18 h after I.P. inj. of a minimum curative dose (mcd) show: (a) increase in size, (b) fragmentation of the kinetoplast DNA, (c) nuclear elongation, and (d) fragmented nucleoli. The drug-induced increase in predivisional forms could arise from either a stimulation or blockage of cell division.

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Document Details

Document Type
Technical Report
Publication Date
Mar 29, 1979
Accession Number
ADA079507

Entities

People

  • Arthur C. Zahalsky
  • Donal G. Myer

Organizations

  • Southern Illinois University Edwardsville

Tags

DTIC Thesaurus Topics

  • Biological Sciences
  • Biomedical And Dental Materials
  • Blood
  • Cardiovascular System
  • Cell Physiological Processes
  • Cells
  • Chemistry
  • Corn
  • Immune Serums
  • Infection
  • Laboratory Animals
  • Lymphatic System
  • Lymphocytes
  • Organelles
  • Parasitic Diseases
  • Polymeric Films
  • Proteins

Fields of Study

  • Biology
  • Chemistry

Readers

  • Immunology
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech