Inhibition of DNA and RNA Polymerase Reactions by Trypanocidal Drugs. Effect of Aromatic Diamidine and Phenanthridinium Compounds,

Abstract

Several trypanocidal drugs were tested for possible inhibitory activity towards DNA (pol. I) and RNA polymerase. These chemotherapeutically active agents are throught to inhibit nucleic acid syntheses in African bloodstream trypanosomes. In the isolated DNA and RNA reactions those compounds that were most inhibitory include Isometamidium, Berenil (diminazene) and Hydroxystilbamidine. In some cases inhibition of the DNA polymerase reaction could be relieved by the input of additional enzyme and/or template-primer. RNA polymerase activity appeared to be inhibited in direct proportion to the amount of drug bound to the template. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Mar 01, 1979
Accession Number
ADA079510

Entities

People

  • Arthur C. Zahalsky
  • David G. Brown
  • Norman F. Nelson

Organizations

  • Southern Illinois University Edwardsville

Tags

DTIC Thesaurus Topics

  • Acids
  • Amidines
  • Cells
  • Chemical Industry
  • Chemotherapeutic Agents
  • Chemotherapy
  • Enzymes
  • Filter Paper
  • Glass Fibers
  • Inhibition
  • Molecules
  • New York
  • Nucleic Acids
  • Primaquine
  • Standards
  • Template Patterns
  • Trypanocides

Fields of Study

  • Biology
  • Chemistry
  • Medicine

Readers

  • Molecular and Cellular Biochemistry
  • Parasitology and Pharmacology of Malaria.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology