Immunity in Mice to Drug-Attenuated Trypanosoma brucei,
Abstract
Purified, monomorphic bloodstream forms of Trypanosoma brucei were attenuated by in vitro exposure to diminazene (Berenil). Such drug-treated organisms were used to actively immunize mice. The humoral component to the observed protective immunity was examined by mouse protection tests using fractionated sera and by the passive transfer of peritoneal exudate cells or spleen cells. The protective immunity of the humoral component is attributable to both IgM and IgG. Immunity following transfer of peritoneal exudate- or spleen cells is due, at least in part, to release of antibody by the transferred cells. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1979
- Accession Number
- ADA079514
Entities
People
- Arthur C. Zahalsky
- Donal G. Myer
Organizations
- Southern Illinois University Edwardsville