Metabolic Disposition of Labeled WR-158,122 in Bile-Duct Cannulated and Bile-Duct Ligated Rats and in a Monkey.

Abstract

Blood levels, excretion, and tissue distribution of WR-158,122 14C were studied in one monkey, 7 bile-duct cannulated rats, 8 bile-duct ligated rats and 2 control rats. The monkey necropsied at 12 hours after dosing excreted 1.8% of the dose in urine and none in feces. It retained 93.6% of the dose in the gastrointestinal tract plus contents. The stomach contained 77.1 percent of the dose, and as a result there was very little drug and/or its metabolites in any other tissue.

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Dec 20, 1979
Accession Number
ADA079759

Entities

People

  • Carl C. Smith
  • David H. Bauman
  • Gary L. Keller
  • Geraldine F. Wolfe
  • Steele F. Mattingly

Organizations

  • University of Cincinnati

Tags

DTIC Thesaurus Topics

  • Animals
  • Biliary Tract
  • Biomedical Research
  • Blood
  • Catheters
  • Environmental Health
  • Excretion
  • Gastrointestinal Tract
  • Intestines
  • Laboratory Animals
  • Large Intestine
  • Metabolites
  • Rhesus Monkeys
  • Small Intestine
  • Tendons
  • Tissues
  • Veins

Fields of Study

  • Biology
  • Medicine

Readers

  • Toxicology/Environmental Toxicology