Inhalation Toxicities of N,N-Diethyl-Meta-Toluamide (M-Det), January - May 1979.
Abstract
No toxic signs were seen in the six male rats exposed to saturated vapor of m-Det at room temperature for an 8-hour exposure period. Transient hyperemia was seen in rats during the 100 C m-Det saturated vapor exposure. The acute aerosol LC50 for rats was 5950 mg/cu m. Transient toxic signs were seen in the rats and dogs exposed to m-Det during the 13-week subchronic inhalation study. Toxic signs ranged from red exudate around the eyes and noses of the rats exposed to 1500 mg/cu m of m-Det to periodic vomiting of dogs exposed to 750 and 1500 mg/cu m of the test compound. No gross or histological lesions were attributable to the inhalation of m-Det aerosol. M-Det may have induced spermhead abnormalities in rats under the condition of the subchronic inhalation exposure, although the observed effects were small. It is concluded that inhalation of m-Det insect repellent at the 750 mg/cu m level and below presents little acute inhalation hazard to man. Concentrations above this level may cause transitory eye and respiratory irritation. M-Det may induce spermhead abnormalities at the high concentration (1500 mg/cu m) tested, although the observed effects were small. Behavioral changes were evidenced at all exposure levels, but their significance to human health is unknown. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 21, 1980
- Accession Number
- ADA079960
Entities
People
- Jeffrey D. Bergmann
- Joseph A. Macko
Organizations
- United States Army Medical Command