Chemotherapeutic Studies on Schistosomiasis.

Abstract

The collaborative antischistosome drug testing program between the University of Brasilia and the U.S. Army Medical Research Unit (WRAIR) Brasilia continues to screen new chemical compounds for prophylactic and curative activity against shcistosomiasis mansoni. The Primary Mortality Test (PMT) is a prophylactic test system which uses mice exposed to 3,000 or more S. mansoni cercariae. The laboratory Biomphalaria glabrata snail colony supported a daily inventory of 1,000 to 1,200 S. mansoni infected snails. The weekly cercarial collections of three to five million were more than adequate to infect prophylactic test group mice with 3,000 or more cercariae each. A total of 1,195 drugs were tested for prophylactic and/or curative activity; of these drugs 538 were tested in the PMT, 218 of these being confirmatory retests. Results of prophylactic testing were: 396 drugs negative or unconfirmed active; 136 drugs toxic; 6 drugs confirmed active.

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1978
Accession Number
ADA080118

Entities

People

  • Aluizio Roza Prata
  • Myron G. Radke

Organizations

  • University of Brasília

Tags

DTIC Thesaurus Topics

  • Animals
  • Biomedical Research
  • Brazil
  • Chemical Compounds
  • Health Services
  • Infection
  • Infection Control
  • Laboratory Animals
  • Life Cycles
  • Medical Personnel
  • Perfusion
  • Research Management
  • Schistosoma Mansoni
  • United States
  • Veins
  • Worms
  • Wound Infections

Fields of Study

  • Medicine

Readers

  • Marine Ecological Systems Migration
  • Oncology (Cancer Research).
  • Virology (or Medical Virology).