Metabolic Disposition of Labeled WR-158,122 in a Bile Duct Cannulated Rhesus Monkey.
Abstract
A 4 kg female rhesus monkey with a bile duct cannula was administered two single oral doses of 14C-labeled WR-158,122. The first dose was given 7 days after initial surgery and the second dose 9 days later. Part (approximately 50%) of the first dose was lost by vomiting but the entire second oral dose was retained. Following the first treatment total excretion of drug in the urine (13.1%) and feces (32.8%) was equivalent as 14C to 45.9% of the dose, not corrected for loss from vomiting. An additional 4.12% was excreted in the bile of which about 75% was returned to the animal. Following the second 5 mg/kg oral dose excretion (as14C) in the urine (21.5%) and feces (72.8%) accounted for 94.3% of the dose. An additional 9.4% was excreted in the bile and again about 75% was returned. These data indicate that at least in this monkey WR-158,122 is moderately absorbed and to a limited degree excreted via the bile. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 18, 1980
- Accession Number
- ADA081244
Entities
People
- Carl C. Smith
- David H. Bauman
- Gary L. Keller
- Geraldine F. Wolfe
- Steele F. Mattingly
Organizations
- University of Cincinnati