Canine Autoanticoagulation during Extracorporeal Perfusion.
Abstract
This laboratory has developed a procedure for extracorporeal perfusion without administration of anticoagulants. The present study was designed to determine extra- and intracorporeal requirements for the development of the incoagulable state, to investigate the biologic stability of the perfusion system, and to better define the nature of the hypocoagulable state. Anesthetized dogs were on extracorporeal perfusion without exogenous anticoagulation at flows exceeding 800 ml/min. Within 45 minutes of perfusion, blood drawn from the animal was incoagulable (clotting time > 24 hr), and within 3 hr following discontinuation of perfusion, clotting time returned to normal. Requirements for the autoanticoagulated state were a perfused liver and a pump in the perfusion circuit.
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 19, 1979
- Accession Number
- ADA081258
Entities
People
- Beverly Beller-todd
- F. B. Taylor Jr
- Lerner B. Hinshaw
- Linda T. Archer
- T. L. Murphy
Organizations
- University of Oklahoma Health Sciences Center