The Effect of Glucagon on Hepatic Cellular Energetics During a Low Flow State,

Abstract

An investigation of the effect of glucagon on liver high energy phosphate concentration during a low flow state is presented. Two groups of dogs were subjected to a 120 minute period of hemorrhagic hypotension followed by re-infusion of shed blood plus additional normal saline to restore the central venous pressure to 10 cm H2O. One group received in addition, intravenous glucagon. Despite a significant increase in portal flow and oxygen delivery, and a significant increase in liver glucose associated with glucagon administration, there was significant impairment in the ability of the liver to regenerate ATP. Evidence is presented to show the decreased ATP concentration was not hepatic blood flow related but was presumably due to increased catabolism. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Jan 01, 1979
Accession Number
ADA081665

Entities

People

  • H. J. Proctor
  • James J. Wood
  • William G. Palladino

Organizations

  • University of North Carolina at Chapel Hill

Tags

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Blood Flow
  • Blood Transfusions
  • Cellular Structures
  • Electrons
  • Free Energy
  • Hemorrhage
  • Hemorrhagic Shock
  • Hydrolysis
  • Ligation
  • Measurement
  • Metabolism
  • Oxygenation
  • Respiration
  • Tissues
  • Veins

Readers

  • Cardiovascular Physiology