Ribavirin Treatment of Toga-, Arena- and Bunyavirus Infections in Subhuman Primates and Other Laboratory Animal Species

Abstract

Ribavirin was effective in reducing viremia and increasing the number of survivors compared to untreated monkeys infected with Rift Valley fever (a bunyavirus), Lassa or Machupo (both arenaviruses) viruses. Treatment was effective when given initially at the time of virus inoculation or later, after the onset of viremia and fever. Only minimal effect was evident against yellow fever virus (a flavivirus) infection in rhesus monkeys, even when treatment was initiated within 8 hours after virus inoculation. Ribavirin was ineffective against Chikungunya virus (an alphavirus) infection of monkeys. The apparent inability of ribavirin to achieve effective concentrations in the central nervous system may limit its usefulness against viruses causing primary encephalitis.

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Document Details

Document Type
Technical Report
Publication Date
Sep 01, 1979
Accession Number
ADA083561

Entities

People

  • Clarence J. Peters
  • Dennis E. Jones
  • Edward L. Stephen
  • Gerald A. Eddy
  • Peter S. Loizeaux

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

DTIC Thesaurus Topics

  • Antiviral Agents
  • Arbovirus Infections
  • Biomedical Research
  • Cell Line
  • Cells
  • Diseases And Disorders
  • Infection
  • Infectious Diseases
  • Nervous System
  • Rhesus Monkeys
  • Rift Valley Fever
  • Rna Viruses
  • Rodents
  • Virus Diseases
  • Viruses
  • Yellow Fever
  • Zoonoses

Fields of Study

  • Biology

Readers

  • Systems Analysis and Design
  • Virology (or Medical Virology).