Carcinogenic Potential of Cholesterol Oxidation Products

Abstract

In a pilot experiment we found striking indication that the inclusion in the diet of a dehydrated egg and milk powder, which is produced for human consumption, induced a high incidence of liver tumors in mice. We postulated that the carcinogen(s) might be oxidation products of cholesterol. Subsequent pilot experiments revealed an increase in the incidence of liver tumors after brief inclusion in the diet of 1.0% 5,6-epoxide of cholesterol, but not after prolonged inclusion of 0.1% 3,5,6-trihydroxycholesterol.

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Document Details

Document Type
Technical Report
Publication Date
Apr 15, 1980
Accession Number
ADA083642

Entities

People

  • Elizabeth H. Leduc

Organizations

  • Brown University

Tags

DTIC Thesaurus Topics

  • Body Weight
  • Breeding
  • Carbohydrates
  • Cells
  • Cholesterol
  • Digestive System Processes
  • Electron Microscopy
  • Epithelial Cells
  • Fungi
  • Glycogen
  • Inclusions
  • Microscopy
  • Military Research
  • Neoplasms
  • Oxidation
  • Transmission Electron Microscopy

Fields of Study

  • Biology

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