Gem-Difluoroallithium: Improved Synthesis Brings Improved Applicability.
Abstract
The action of N-butyllithium in hexane on CF2BrCH=CH2/CF2=CH-CH2Br (5:2 yield 20:1 mixture) in 5:1:1 THF/Et2O/pentane at -95 degrees C generates gem-difluoroallyllithium which may be trapped, generally in good yield, by the in situ procedure using triorganochlorosilanes (yield R3SiCF2CH=CH2) and aldehydes and ketones (yield RR'C(OH)CF2-CH=CH2). (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 15, 1980
- Accession Number
- ADA083967
Entities
People
- Dennis J. Sepelak
- Dietmar Seyferth
- Helmut A. Klein
- Robert M. Simon
Organizations
- Massachusetts Institute of Technology