Immunomodulation in vivo during Tularemia in AKR/J Mice
Abstract
The anti-sheep red blood cell (SRBC) primary in vivo immune response was used to measure immunomodulation during tularemia infection in AKR/J mice. Three periods of altered immune response ability were noted in the 30-day period after subcutaneous inoculation. These effects, in sequence, were: early augmentation, suppression with maximum at day 12 and late augmentation at day 30. These altered immune responses correlated most directly to Francisella tularensis antigen load in the spleen. However, other infection-related phenomena (notably decreased nutrition) occur which may cause some immunomodulation.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 29, 1980
- Accession Number
- ADA084720
Entities
People
- Dale W. Seburn
- H. M. Howell
Organizations
- United States Army Medical Research Institute of Infectious Diseases