Central Nervous Ionic Homeostasis (Ionic Regulation by the Insect Blood-Brain Barrier).
Abstract
This investigation has used invertebrate nervous systems to elucidate two basic aspects of central nervous ionic homeostasis: neuronal adaptations to ionic and osmotic stress and ionic homeostasis of the brain microenvironment. The research on the giant axons of polychaetes has established the important principle that some nerve cells can adapt to very large changes in the composition of their immediate fluid environment. These adaptations involve structural modification and changes in the cellular mechanisms which mediate excitation and conduction. The results of the investigation on the insect central nervous system has shed light on the permeability properties of the blood-brain interface, which shares some features with the functional organization of the mammalian central nervous system. The physiological information obtained has enabled a physiological model to be erected which explains all of the available experimental information and should be susceptible to further experimental tests. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1980
- Accession Number
- ADA084823
Entities
People
- John E. Treherne
Organizations
- University of Cambridge