Comparison of Some Physical and Immuologic Properties of a Phase I and a Phase II Q Fever Vaccine in Guinea Pigs.

Abstract

A highly purified phase I Q fever vaccine was evaluated by comparing its physical, serologic and protective properties with those of a phase II vaccine currently in use. The concentration of rickettsiae was approximately the same in both preparations. The phase I vaccine had a median protective dose in guinea pigs of 1.8 micrograms, compared with 27.3 micrograms needed for the phase II vaccine. Median doses required for detectable serum complement-fixing, microagglutinating and immunofluorescing antibodies were also lower by factors of 1.5 to 20 times for the phase I vaccine. (Author)

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Document Details

Document Type
Technical Report
Publication Date
May 09, 1980
Accession Number
ADA085937

Entities

People

  • C. E. Pedersen Jr.
  • G. A. Higbee
  • J. W. Johnson
  • R. F. Wachter

Organizations

  • United States Army Medical Research Institute of Infectious Diseases

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Antibodies
  • Biomedical Research
  • Cells
  • Diseases And Disorders
  • Infectious Diseases
  • Laboratory Animals
  • Materials
  • Physical Properties
  • Q Fever
  • Research Facilities
  • Rodents

Fields of Study

  • Biology
  • Medicine

Readers

  • Mathematics or Statistics
  • Nuclear Civil Defense.
  • Virology (or Medical Virology).

Technology Areas

  • Biotechnology