The Effects of Erythrocyte Intermediates on Oxygen Dissociation Properties of Hemoglobin.
Abstract
The biochemical mechanisms by which the erythrocyte elevates its 2,3-diphosphoglycerate and decreases its oxygen affinity were studied. It appears that a complex set of mechanisms involving the rate limiting enzymes of glycolysis, hexokinase, phosphofructokinase, and pyruvate kinase, are involved. Secondly, an approach to preadaptation to altitude was attempted using pharmacological means. Orally administered phosphate was used in a double-blind study involving 20 subjects taken to Pikes Peak (altitude 4300 m). While differences were not large, the phosphate-treated group had better overall performance in a number of areas compared to the placebo group. Some differences reach statistical significance. These results suggest that a drug with greater effect on reducing oxygen affinity than phosphate might have very salutary effects in altitude preadaptation. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1979
- Accession Number
- ADA086164
Entities
People
- George J. Brewer
Organizations
- University of Michigan