Chemotherapy of Leishmaniasis.

Abstract

Simplified screening procedures for in vivo evaluation in mice of potential antileishmanial compounds are described in this report. Data are provided on the antileishmanial activity of 12 WRAIR compounds and 6 other compounds against a visceral parasite, L.infantum (LV9), and two cutaneous parasites, L.major (LV39) and L.m.amazonensis (LV78). The taxonomic status of a number of newly isolated strains of Leishmania is described and an updated list of isolates maintained in the reference collection is appended. Other work has involved studies on antimonial leishmanicides in liposomes, separation of amastigotes from tissue using a cellulose column, purine and pyrimidine synthesis in L.m.amazonensis promastigotes and immunological studies of visceral and cutaneous leishmaniasis. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Dec 01, 1978
Accession Number
ADA086350

Entities

People

  • Wallace Peters

Organizations

  • Liverpool School of Tropical Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Animals
  • Antileishmanial Drugs
  • Cell Nucleus
  • Cells
  • Chemistry
  • Chemotherapy
  • Control
  • Diseases And Disorders
  • Health Services
  • Infection
  • Leishmania
  • Leishmaniasis
  • Macrophages
  • Materials
  • Metabolism
  • Parasitology
  • Tropical Medicine

Readers

  • Aerospace Engineering.
  • Infectious Disease/Epidemiology
  • Molecular and Cellular Biochemistry