Neurotoxic Properties on Endotoxins.
Abstract
Some endotoxins produce a biphasic effect on spontaneous transmitter secretion, with an early facilitation of release, but a monotonic depression of evoked release triggered by nerve stimulation, while lipopolysaccharide produces only a monotonic depression of both spontaneous and evoked transmitter secretion under physiological conditions. However, glycolipid produces a biphasic effect on both spontaneous and evoked release. This suggests that the variety of effects seen in less pure preparation of glycolipids are modulations of the biphasic pattern of action resulting from differences in extraction procedures, presence of polysaccharide, or contamination of the specific endotoxin preparation employed. Based on these experiments we have proposed experimentally based mechanisms for the action of bacterial glycolipid: (1) an early, transient ionophoric action for calcium which facilitates secretion and (2) a late increasing isolation of the membrane from extracellular space. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1980
- Accession Number
- ADA086362
Entities
People
- Robert J. Person
Organizations
- University of Oklahoma Health Sciences Center