The Effects of Acute Alterations in Hemodynamics, Oxygen Availability, and Acid-Base Balance on the Permeability of the Gastric Mucosa.
Abstract
Using a previously described model for acute gastric mucosal ulcerogenesis, developed under the auspices of the current contract, studies from this laboratory during the period covered by this progress report indicate (1) that, in the face of an imposed topical acid load, H1 and H2 receptor blockade, either alone or in combination, effects no change in gastric mucosal permeability to cations or in mucosal blood flow and affords no protection against bile acid-ischemia induced ulcerogenesis; (2) that the addition of exogeneous histamine neither protects nor augments lesion formation under these circumstances; (3) that the dihydroxy secondary bile acids are more damaging to gastric mucosa than are the trihydroxy primary bile acids; and (4) that in non-ischemic bile acid-treated gastric mucosa, mucosal blood flow increases in proportion to the magnitude of H 'back-diffusion' induced, a response not mediated by histamine receptors. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Mar 01, 1980
- Accession Number
- ADA087628
Entities
People
- Wallace P. Ritchie Jr.
Organizations
- University of Virginia