Synthesis of 6-Substituted-2,4-Diamino-5,6,7,8-Tetrahydropyrimido(4-5-d)Pyrimidines.

Abstract

A series of sixteen target compounds involving primarily methylene, ethylene and methyleneoxy spacers between the heterocyclic portion and halogenated phenyl portion were prepared and submitted for screening. The chemistry and biological screening results are described. None of the compounds exhibited useful chemotherapeutic activity. (Author)

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Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1979
Accession Number
ADA088754

Entities

People

  • Thomas J. Delia

Organizations

  • Central Michigan University

Tags

DTIC Thesaurus Topics

  • Amines
  • Antimalarials
  • Chemical Synthesis
  • Chemistry
  • Column Chromatography
  • Formaldehyde
  • Mass Spectra
  • Materials
  • Melting Point
  • Methylenes
  • Mixtures
  • Organic Chemistry
  • Pyrimidines
  • Silica Gels
  • Sodium Hydroxide
  • Spectra
  • Technical Information Centers

Fields of Study

  • Chemistry

Readers

  • Clinical Trial Research.
  • Molecular and Cellular Biochemistry
  • Organic Chemistry