The Role of Endorphins in the Pathophysiology of Shock and the Therapeutic Benefit of Opiate Antagonists,

Abstract

Evidence is presented that the pure opiate antagonist naloxone rapidly increases blood pressure and decreases mortality associated with shock caused by endotoxemia, hemorrhage, and spinal-cord transection. Shock studies conducted in rats, cats, and dogs demonstrate these therapeutic effects of naloxone across a variety of species. Additionally, naloxone treatment significantly improves neurologic recovery (paralysis) after spinal-cord injury in the cat. Results from additional experiments provide evidence for the site and mechanisms of these therapeutic effects of naloxone.

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Document Details

Document Type
Technical Report
Publication Date
Jun 01, 1980
Accession Number
ADA090403

Entities

People

  • Alan I. Faden
  • John W. Holaday

Organizations

  • Walter Reed Army Institute of Research

Tags

Communities of Interest

  • Counter IED

DTIC Thesaurus Topics

  • Arteries
  • Blood
  • Cardiovascular Diseases
  • Cardiovascular Physiological Phenomena
  • Endotoxic Shock
  • Heart Rate
  • Hemorrhagic Shock
  • Jugular Vein
  • Laboratory Animals
  • Nervous System
  • Spinal Cord
  • Spinal Injuries
  • Veins

Fields of Study

  • Biology
  • Chemistry
  • Medicine
  • Psychology

Readers

  • Cardiovascular Physiology
  • Combustion Dynamics and Shock Wave Physics.
  • Trauma Surgery or Emergency Medicine.