Contractile State of the Heart during Hypovdemic Shock and Entotoxemia.
Abstract
It was demonstrated that myocardial depression was not needed for the lethal progression of hemorrhagic shock. Furthermore, assays of fresh serum from animals in hermorrhagic shock resulted in an increase in the developed force of the muscles tested. A minimal degree of depression was demonstrated only if the serum were frozen prior to assay. Utilizing an isolated supported heart preparation, it was demonstrated that short periods of graded hypotension led to complete recovery following reperfusion as indicated by peak isovolemic pressure drops, peak dP/dT and vmax. Ventricular performance declined 'roughly' in proportion to the perfusion pressure down to a level of 30-35 mm Hg.
Document Details
- Document Type
- Technical Report
- Publication Date
- Apr 01, 1980
- Accession Number
- ADA090498
Entities
People
- Charles W. Urschel
- Edmund W. Sonnenblick