Neuropharmacology and Therapeutics of AF Chemicals

Abstract

In a continuing evaluation of mechanisms underlying convulsions produced by monomethylhydrazine (MMH) we have attempted to compare this response to seizures produced by a non-toxic, chronic experimental model of current interest in epilepsy (kindling). A series of studies were directed towards a comparison of seizure susceptibility, the protective effects of pyridozine and the therapeutic effects of thalamic lesions on both models. A significant correlation was obtained between MMH seizure latencies and initial afterdischarge thresholds for kindling in the same animals. Moreover, pyridoxine provided substantial protection against MMH seizures and a slight but consistent elevation of seizure thresholds with the kindling model. Finally lateral thalamic lesions significantly reduced seizure susceptibility with both models. The physiological and therapeutic implications of these findings are discussed.

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Document Details

Document Type
Technical Report
Publication Date
Aug 01, 1980
Accession Number
ADA090679

Entities

People

  • M. B. Sterman
  • M. D. Fairchild
  • M. N. Shouse

Organizations

  • UCLA David Geffen School of Medicine

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Anticonvulsants
  • Biomedical Research
  • Brain
  • California
  • Central Nervous System
  • Epilepsy
  • Hydrazines
  • Nervous System
  • Neurosciences
  • Pharmacology
  • Seizures
  • Therapy

Fields of Study

  • Biology
  • Psychology

Readers

  • Neuroscience
  • Toxicology/Environmental Toxicology