Lassa Virus Infection of Rhesus Monkeys: Pathogenesis and Treatment with Ribavirin
Abstract
Rhesus monkeys were experimentally infected with Lassa virus to establish their suitability as a nonhuman primate model for the human diseases and to test the protective efficacy of ribavirin, an antiviral drug. Six of 10 untreated control monkeys died after subcutaneous inoculation of 10 (epxn 6.1) plaque-forming units of Lassa virus (strain Josiah). Infectivity titrations of tissues homogenates from the six dead monkeys indicated significant replication in all tissues tested except the central nervous system. This distribution of virus was confirmed by direct immunofluoresence examination of cryostat-sectioned tissues. Ribavirin was beneficial in the treatment of two groups of infected monkeys. Four monkeys first treated on the day of viral inoculation experienced only mild clinical disease; four monkey first treated five days later experienced a more severe illness. None of the eight monkeys treated with ribavirin died. Viremia titers and elevations of levels of serum tarnsaminases in treated monkeys were significantly lower than in controls. Ribavirin may be beneficial in the treatment of humans exposed to this life-threatening virus.
Document Details
- Document Type
- Technical Report
- Publication Date
- May 01, 1980
- Accession Number
- ADA090915
Entities
People
- G. A. Eddy
- K. M. Johnson
- P. B. Jahrling
- R. A. Hesse
- R. T. Callis
Organizations
- United States Army Medical Research Institute of Infectious Diseases