Histamine Receptor Control of Gastric Microvasculature in Shock
Abstract
Control of gastric mucosal blood flow in hemorrhagic shock was investigated, in an anesthetized miniature swine model, using H sub 1 -receptor (diphenhydramine) and H sub 2 -receptor (cimetidine) antagonisms. The animals were divided into two experimental groups: (i) diphenhydramine treatment; and (ii) diphenhydramine plus cimetidine treatment. Results were compared to previously reported untreated controls and animals who received cimetidine alone. Conclusions reached were: (1) Histamine receptors in the gastric microvasculature do play a role in the control of mucosal blood flow during shock. (2) H sub 2 -Receptor antagonism, whether alone or in conjunction with H sub 1 -receptor antagonism, results in significant protection against a shock-related decrease in gastric mucosal blood flow. (3) H sub 1 -Receptor antagonism does not affect gastric mucosal blood flow in shock.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jan 01, 1979
- Accession Number
- ADA091340
Entities
People
- Barry A. Levine
- David R Jones
- Kenneth R. Sirinek
- Wayne H. Schwesinger
Organizations
- United States Army Institute of Surgical Research