Role of Lysosomal Enzyme Release in Circulatory Shock and Critical Illness.
Abstract
To determine the association of lysosomal enzyme release and the severity of shock in the human system in states of circulatory shock, studies were carried out on (1) the release of lysosomal enzymes in several forms of clinical trauma and (2) the role of administration of agents that may modify the release of lysosomal enzymes. The appearance of cathepsin D in the circulation of experimental animals subjected to hemorrhagic shock is predictable and reflects the duration and severity of shock. Increases in plasma cathepsin D activity occur early in the course experimental hemorrhagic shock, suggesting that disruption of normal lysosomal membrane function is an early event in the progression of circulatory shock. The results, however, do not show any adverse effects from the introduction of exogenous cathepsin D into the systemic circulation during hemorrhagic shock and cathepsin D would appear to be inactivated at pH of blood normally found in shock. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Jun 01, 1978
- Accession Number
- ADA091635
Entities
People
- Stephen L. Wangensteen
Organizations
- University of Virginia