Elevated Glycosyltransferase Activities in Infected or Traumatized Hosts: Nonspecific Response to Inflammation
Abstract
Streptococcus pneumoniae infection leads to multifold increases in sialyltransferase, galactosyltransferase, alpha sub 2 -fucosyltransferase, and alpha sub 3 -fucosyltransferase activity of rat liver. Such changes may reflect an increased demand for glycosylation of acute-phase proteins synthesized and secreted by the liver during inflammatory processes. Serum sialyltransferase became elevated in bacteria-infected or burned rats and sandfly fever-infected humans, but did not correlate with acute-phase serum protein changes. These data suggest that nonparenchymal liver cells, such as macrophages, may contribute substantially to elevated sialyltransferase activity in the circulation during infection and, as such, represent a general host response to infection and tissue trauma.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1980
- Accession Number
- ADA091920
Entities
People
- J. S. Little
- K. A. Bostian
- M. C. Powanda
- P. G. Canonico
- W. R. Beisel
Organizations
- United States Army Medical Research Institute of Infectious Diseases