Evaluation of ERG as a Model of Cerebral Tissue PO2 Changes with Environmental Stress

Abstract

The amplitude and latency of the a- and b-waves of the electroretinogram (ERG) and cerebral oxygenation (PO2) were measured in the rhesus macaque as a function of hypoxic and stagnant hypoxia caused by increasing altitude (decreasing ambient PO2) and G sub z (centrifugal force induced by a centrifuge), respectively. Previous studies had shown a decrease in the amplitude of the ERG b-wave in response to anoxia or retinal ischemia. The a-wave was relatively unaffected. The present study was designed to determine the relationship between cerebral PO2 and ERG parameters under two types of hypoxic conditions. As an extension of the central nervous system (CNS), the retina may serve as a physiological correlate of cerebral tissue PO2. Good correlation of one or more ERG metrics with cerebral oxygenation would allow the use of a non-invasive technique to monitor cerebral PO2.

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Document Details

Document Type
Technical Report
Publication Date
Jul 01, 1980
Accession Number
ADA092714

Entities

People

  • A. A. Karl
  • A. T. Kissen
  • D. R. Nelson
  • S. L. Ward

Tags

Communities of Interest

  • Biomedical

DTIC Thesaurus Topics

  • Air Force
  • Air Force Facilities
  • Altitude
  • Altitude Chambers
  • Amplitude
  • Biomedical Research
  • Blood Flow
  • Brain
  • Central Nervous System
  • Classification
  • Correlation Analysis
  • Data Science
  • Information Science
  • Linear Regression Analysis
  • Nervous System
  • Regression Analysis
  • Security

Readers

  • Brain and Cognitive Science; Experimental Psychology; Cognitive Neuroscience
  • Immunology and Pathology
  • Vision Science/Vision Psychology/Cognitive Neuroscience.