Phase 8, Dermal Penetration of Radiolabeled Repellent N,N-Diethyl-m-toluamide (m-Det), January 1979 - June 1980,
Abstract
The dermal penetration of 14C-labeled m-Det was measured in rats, rabbits, and dogs. Absorption was quantitated by monitoring radioactivity in excreta for 7 days and tissues at necropsy. Pregnant rabbits were repeatedly applied with the repellent and fetuses monitored for radioactivity at term. It is concluded that topically applied m-Det should not present a dermatoxic hazard to man and absorption would be expected to be less than 10 percent of the applied dose. No affinity for specific tissue binding of the repellant has been demonstrated in these tests. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Dec 05, 1980
- Accession Number
- ADA092937
Entities
People
- Douglas C. Nelson
- Hubert L. Snodgrass Jr.
- Maurice H. Weeks
Organizations
- United States Army Medical Command