Phase 7, Effect of Dermal Applications of N,N-Diethyl-meta-toluamide (m-Det) on the Embryonic Development of Rabbits, March 1979 - July 1980,
Abstract
Daily dermal applications of an ethanol solution of m-Det were administered to pregnant rabbits from day 1 through day 29 of gestation. Dosages were selected as fractions of the dermal LD50 for that species (50, 100, 500 and 1000 mg/kg/day corresponding to 1/100, 1/50, 1/10, and 1/5 of the LD50). Repeated applications of a 75 percent solution of m-Det caused moderate to severe skin irritation in rabbits with the degree of irritation dependent upon the daily dosage. It would be expected to cause irritation to human skin upon repeated applications at high concentrations if the skin is left unwashed. All maternal and fetal indices were within normal limits. The single abortions occurring in each of the highest two dosage groups were presumed to be spontaneous events caused by handling the animals or the discomfort of the skin irritation. M-Det was not shown to be a teratogen in rabbits and would not be expected to cause birth defects in humans. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Feb 02, 1981
- Accession Number
- ADA094778
Entities
People
- Maurice H. Weeks
- Richard A. Angerhofer
Organizations
- United States Army Medical Command