Photobacterial Response to Cadmium Chloride, Mercuric Chloride, and Selenium Dioxide: Dose-Response and Interaction Studies.
Abstract
An ideal biologic toxicity screening system would have the following characteristics: (1) test organisms are simple to maintain, (2) organisms should possess a reproducible and easily measured endpoint, (3) simultaneous testing of a large number of individuals is permitted, (4) screening of several chemicals during each screening test is permitted, (5) the duration of each screening test is of reasonable length, and (6) the response of the organisms is dose dependent. The photobacterial toxicity screening system used in this study meets these criteria: the photobacteria are easily grown in a liquid medium and require subculturing once daily; their luminescent response is reproducible and accurately measured by a photometer; a large number of chemicals may be screened during an 8- to 9-hour span; and the response of the photobacterial bioluminescent activity is dose dependent to at least one group of compounds tested-nitrotoluenes. The objective of this study was to determine the dose-response characteristics of the photobacterial toxicity screening system (PTSS) when challenged by cadmium chloride, mercuric chloride, and selenium dioxide in aqueous solutions and to determine the response of the PTSS to various combinations of these three compounds.
Document Details
- Document Type
- Technical Report
- Publication Date
- Jul 01, 1980
- Accession Number
- ADA094903
Entities
People
- Paul H. Gibbs
- Ronald N. Shiotsuka
- Susana Allongo
Organizations
- United States Army Medical Research and Development Command