The Effect of a Low Fluoride Delivery System on Bacterial Metabolism.
Abstract
This contract dealt with the incorporation and slow release of various fluoride compounds in temporary restorative materials to impart antiplaque and anticaries activity to the restorative material. In the first phase of the study we examined the effect of various fluoride compounds on bacterial growth, metabolism and attachment. We found that 10 ppm F(-), a concentration that is compatible with a slow release agent, as well below bacterial growth inhibition or bactericidal levels. However, all fluoride compounds at this concentration produced decreased acid production of plaque forming organisms. As well, Na2SnF6, NaF and SnF2 appeared to affect the attachment mechanisms of S. mutans to enamel, with SnF2 being the most effective. An increase in both alkali and water soluble glucans of the bacteria suggest that fluoride at low levels produces unbalanced growth. The large accumulation of tin found in those organisms treated wtih SnF2 may account for the increased effectiveness of SnF2. From this series of experiments, it appears that continuous exposure of SnF2 (10 ppm F(-)) has the most effect on S. mutans growth, metabolism and attachment.
Document Details
- Document Type
- Technical Report
- Publication Date
- Sep 01, 1980
- Accession Number
- ADA095069
Entities
People
- David Camosci
- Norman Tinanoff
Organizations
- University of Connecticut Health Center