Search for Radioprotective Compounds. Part XIX. Protection Provided to Mice by Oral Administration of Lipid- and Water-Soluble Compounds,
Abstract
Forty-two compounds previously screened at the Walter Reed Army Institute of Research were selected for further evaluation. The compounds were administered orally to mice prior to gamma irradiation. The LD sub (50/30) was computed and dose reduction factors determined. Dose radiation factors up to 1.45 were obtained for both water- and lipid-soluble compounds with administered oral doses of 100 mg/kg or less. The relationship between chemical structure and protective activity of the compounds is discussed. (Author)
Document Details
- Document Type
- Technical Report
- Publication Date
- Oct 01, 1980
- Accession Number
- ADA095715
Entities
People
- George A. Grant
- Karen E. Leach
Organizations
- Defence Research and Development Canada