A Study of Adverse Gastrointestinal Effects of 8-Aminoquinolines.

Abstract

Investigations were carried out to elucidate the mechanism of adverse effects of experimental antimalarial compounds on the gastrointestinal tract. Most of the experimental work used primaquine as a prototype 8-aminoquinoline. This compound was found to have anticholinergic and motility inhibiting effects on the gut from several species. A method for the assessment of the relative potency of these effects was developed and 12 compounds were compared. All compounds tested had significant depressant effect on the motility of the isolated rabbit intestine. These quantitative results may allow comparison of the discomfort producing capacity of the 8-aminoquinoline series when testing in man is possible. (Author)

Open PDF

Document Details

Document Type
Technical Report
Publication Date
Oct 01, 1980
Accession Number
ADA096922

Entities

People

  • Edward R. Seidel
  • Robert S. Teague
  • Roy L. Mundy

Organizations

  • University of Alabama at Birmingham

Tags

DTIC Thesaurus Topics

  • Abstracts
  • Analysis Of Variance
  • Antimalarials
  • Confidence Limits
  • Gastrointestinal Tract
  • Human Behavior
  • Intestines
  • Measurement
  • Medical Personnel
  • Pharmacology
  • Plastic Explosives
  • Regression Analysis
  • Rodents
  • Sensitivity
  • Serotonin Agents
  • Smooth Muscle
  • Students

Readers

  • Cardiovascular Physiology
  • Parasitology and Pharmacology of Malaria.